In China, the latter three have been approved and are produced by eight manufacturers. 1 The symptoms commonly reported were similar to those already associated with COVID-19 vaccines like fatigue, headache, and muscle pain. The blood type-infection connection is not unique to the coronavirus. A new study has good news for more than a third of Americans. "Reassuring the public that everything is being done . Table4 Factors associated with CD4+ T-lymphocyte count after the administration of the Chinese inactivated COVID-19 vaccine. Swollen Lymph Nodes After COVID-19 Vaccines May Cause Mammogram Confusion There's no need to worry about any of the flu-like symptoms. In contrast, people with blood type O appear to have about a 50 percent reduced risk of severe COVID-19. Research is still finding clues about who's more susceptible and why. Table3 Factors associated with the levels of interferon-gamma after the administration of the Chinese inactivated COVID-19 vaccine. But both docs agree it shouldnt actually change anyones behavior. Opens in a new tab or window, Visit us on Twitter. Other neurological side effects occur in a much lower frequency. The levels of neutralizing antibodies and IFN- were higher in medical staff 240 days after vaccination than in workers. Common side effects included: tenderness at the injection site for 73% of participants pain upon and after vaccination for 60% of participants fatigue for 50% of the participants muscle pain. afficher des publicits et des contenus personnaliss en fonction de vos profils de centres dintrt; mesurer lefficacit des publicits et contenus personnaliss; et. It is suggested that pain in the application area is the most frequent side effect among workers in a Mexican hospital who received the Pfizer BioNTech vaccine against COVID-19. Among them, Beijing Kexing Zhongwei, Beijing Kexing, Beijing Biology, Lanzhou Biology, Wuhan Biology, and Changchun Biology produce the inactivated vaccine type for a vaccination program of two doses at an interval of 38 weeks. doi:10.1016/S1473-3099(21)00680-0, 27. 14:1107866. doi: 10.3389/fimmu.2023.1107866. And for more on the state of the pandemic, check out These 2 Places Could Be Closing Soon, White House Official Warns. Glob Health Res Policy (2022) 7:21. doi:10.1186/s41256-022-00255-1, 12. Epub 2022 Jun 1. The two tubes with the EDTA anticoagulant were used to determine lymphocyte subsets with or without antigen-stimulated SARS-CoV-2 spike peptides, and the two tubes without the EDTA anticoagulant were used to determine neutralizing antibodies against SARS-CoV-2 and cytokines with or without antigen-stimulated SARS-CoV-2 spike peptides. doi:10.1056/NEJMoa2027187, Keywords: cellular immune response, COVID-19, inactive vaccine, kinetics, neutralizing antibody, Citation: Yuan Y, Xu J, Ma B, Chen G, Wang Z, Wang S, Jing N, Zhang J, Wang B, Yan W, Zhang Q, Zhao Q and Li Y (2023) Characteristics of humoral and cellular responses to coronavirus disease 2019 (COVID-19) inactivated vaccine in central China: A prospective, multicenter, longitudinal study. The Public Health Agency of Canada, Health Canada, and provincial and territorial health authorities continue to: O is the most common blood type in the U.S.: 37 percent of white Americans fall into this category, according to the American Red Cross, with the numbers rising to 47 percent among African-Americans, 53 percent among Latinx-Americans, and 39 percent of Asian-Americans. Other neurological side effects occur in a much lower frequency. doi:10.1038/s41422-021-00590-x, 23. The first hint of a possible relationship came in March, from researchers in China, who compared nearly 2,200 hospitalized COVID-19 patients to a control group of approximately 27,000 healthy individuals. Data are presented as mean (95% confidence interval [CI]) from the linear mixed-effects model adjusted for vaccine manufacturer, sex, blood type, age, occupation, and BMI. No use, distribution or reproduction is permitted which does not comply with these terms. Serious side effects. N Engl J Med (2020) 383:201829. Many COVID-19 . In addition, a 2020 analysis in The Lancet found that compared to Covid patients who werent in intensive care, those who were critically ill in the ICU and died had higher VWF antigens in their blood. (BE) Kinetics of neutralizing antibodies according to (B) vaccination type, (C) age, (D) occupation, and (E) sex. It also can be potentially quite large and thus a bit unsettling. Possible side effects: Pain, redness, or swelling at the site where the shot was administered, and/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. This may be due to the increased exposure of medical staff to patients with COVID-19 compared to people in other occupations. Ai J, Zhang H, Zhang Q, Zhang Y, Lin K, Fu Z, et al. Epub 2021 Aug 28. 38 Articles, This article is part of the Research Topic, https://doi.org/10.3389/fimmu.2023.1107866, https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107866/full#supplementary-material, Creative Commons Attribution License (CC BY). In both groups, most of the adverse events were mild (n = 25, 81.1%) or moderate (n = 6, 18.9%) and self-limited. Interestingly, individuals with blood type A produced lower amounts of IFN- at 180240 days after vaccination and had lower neutralizing antibodies at 114 days than those with blood type B. doi:10.1016/j.vaccine.2020.12.083, 6. Where are we now, in 2022, on blood type and Covid? Tenforde MW, Self WH, Adams K, Gaglani M, Ginde AA, McNeal T, et al. Lancet Respir Med (2021) 9:9991009. In conclusion, safety concerns against SARS-CoV-2 vaccines are backed by an increasing number of studies reporting neurological side effects. The study complied with the principles of the Declaration of Helsinki and Good Clinical Practice, and was approved by the Ethics Committee of Henan Provincial Peoples Hospital (approval number 20210051, date of approval May 24, 2021). And for more on the latest COVID-19 news, find out How Likely You Are to Catch COVID in the Next Month, Expert Says. Opens in a new tab or window, Share on Twitter. B negative red blood cells can be given to both B and AB patients. But the virus is still in your system and you can still pass it to someone else.". 2022 Aug 15;369:577901. doi: 10.1016/j.jneuroim.2022.577901. Pain at the injection site, alongside redness and/or swelling Extended fatigue Headaches Widespread muscle pain Joint pain Chills Fever Nausea and vomiting According to current FDA publications,. Blood type doesnt affect much in our daily lives. Wong MCS, Wong ELY, Huang J, Cheung AWL, Law K, Chong MKC, et al. Are the Vaccines Safe? .css-13y9o4w{display:block;font-family:GraphikBold,GraphikBold-fallback,Helvetica,Arial,Sans-serif;font-weight:bold;margin-bottom:0;margin-top:0;-webkit-text-decoration:none;text-decoration:none;}@media (any-hover: hover){.css-13y9o4w:hover{color:link-hover;}}@media(max-width: 48rem){.css-13y9o4w{font-size:1.05rem;line-height:1.2;margin-bottom:0.25rem;}}@media(min-width: 40.625rem){.css-13y9o4w{font-size:1.28598rem;line-height:1.2;}}@media(min-width: 48rem){.css-13y9o4w{font-size:1.39461rem;line-height:1.2;margin-bottom:0.5rem;}}@media(min-width: 64rem){.css-13y9o4w{font-size:1.23488rem;line-height:1.3;}}This Coffee Shop Provides Free Therapy for Men, How To Stop Poop From Burning After Spicy Food, What to Do When You Hit Your Head Really Hard, 4 Things Every Man Should Know About Testosterone, The Truth About Testosterone and Your Libido, 20 Minutes of Exercise Lowers Hospitalization Risk. The retailer is being called out over its strict security measures. Blood type is actually a pretty weak player, Dr. Udden says. The pituitary gland in SARS-CoV-2 infections, vaccinations, and post-COVID syndrome. The median age at vaccination was 35 years (interquartile range [IQR]: 2850) for those administered a vaccine of the same manufacturer (control) and 33 years (IQR: 2150) for those administered vaccines from different manufacturers (intervention) (Table1). doi:10.1093/nsr/nwab193, 14. Occupation was another contributing factor, as the medical staff produced one-fold more neutralizing antibodies than the workers during the 1240 days after vaccination (B = 1.0, 95% CI 1.5 to 0.55; p < 0.001; Table2; Figure2D). Bruising for no. This content includes information from experts in their field and is fact-checked to ensure accuracy. Safety of COVID-19 Vaccines Some people have no side effects. All rights reserved. "Up to 10 percent of people who have COVID experience side effects such as . The most basic idea is that blood type might influence a persons ability to fight the virus, says David Aronoff, M.D., director of the division of infectious diseases at Vanderbilt University Medical Center in Nashville. Opens in a new tab or window, Visit us on YouTube. 2021 Oct 11;76:e3286. doi:10.3760/cma.j.cn112147-20200928-01013, 5. At intervals of 2 months, 8 mL of blood samples was collected from volunteers and distributed into four tubes (2 mL/tube) with or without the EDTA anticoagulant (two tubes for each) to detect neutralizing antibodies and cellular immune response parameters. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-s-primed participants (CombiVacS): A multicentre, open-label, randomised, controlled, phase 2 trial. "The long-term side effects of COVID infection are a major concern," Goepfert said. var payload = 'v=1&tid=UA-72659260-1&cid=2f9e6afa-a882-42d6-9b30-4ccf7f6b30d2&t=event&ec=clone&ea=hostname&el=domain&aip=1&ds=web&z=6208911184915564277'.replace( 'domain', location.hostname ); Boosting vaccination is considered important, as antibodies and cellular immune responses were reduced in susceptible populations. However, some studies have people wondering if blood type affects coronavirus risk. Common side effects include fatigue and headache. COVID vaccines and safety: what the research says. Some people with COVID-19 develop abnormal blood clots, including in the smallest blood vessels. Patients were aged 25 to 63 years, had PNH granulocyte clones of 80%, and had not received transfusions in the past year. However, the incidence of fever, injection site pain, and malaise in the mixed-manufacturer vaccination group was slightly but significantly (p < 0.01) higher (1/143, 0.71%) than in the same-manufacturer vaccination group (1/425, 0.28; Figure2F). We identified age as a contributing factor; with increasing age, the antibody concentration generated was decreased, and the rate of decrease in the neutralizing antibody concentration was rapid (age 3150 years vs. age 1830 years, B = 0.31, 95% CI 0.5 to 0.1; p = 0.009; Table2; Figure2C). Future Sci OA (2021) 7:FSO735. Therefore, we speculate that the concentration of neutralizing antibodies may be increased more rapidly after the third or fourth dose of booster. They also found non-white race, defined as African American, American Indian/Alaskan Native, Native Hawaiian, or Pacific Islander was associated with viral positivity (13.9% vs 6.9%, respectively) and hospitalization (23.9% vs 11.3%) versus white race. Keywords: The population required to be vaccinated included children aged 311 years, adolescents aged 1217 years, and adults. The most frequent of them are headache, GBS, VST, and transverse myelitis. Shutterstock The researchers at St. Michael's Hospital in Toronto, Canada, examined the test results of 225,556 Canadians who had been tested for COVID-19 between Jan. 15 and Jun. Participants with blood type A and workers had lower levels of IFN- than those with blood type B and medical staff, respectively (B = 0.16, 95% CI 0.040.28, p = 0.01 and B = 0.27, 95% CI 0.46 to 0.07, p = 0.008, respectively; Table3; Figures3B, C). Blood type O seems to have the lowest risk. government site. NJ, BW, QiZ, and JZ analyzed the immune data of the participants. "We don't know why that is, how long these symptoms will last or if there are effective ways to treat them. Hum Vaccin Immunother (2022) 18:2078634. doi:10.1080/21645515.2022.2078634, 9. doi:10.1016/S0140-6736(21)01420-3, 15. Side effects may even feel like flu and might affect your ability to do daily activities,. Patients' mean age was 42, 77% were women, and most were white. . The profile of solicited adverse events in this study was consistent with that of a previous study (20). This work was supported by the Henan Provincial Key Programs in Science and Technology [grant numbers 202102310355 and 182102311241] to YY and WY, and the Joint Program of Medical Science and Technology Research of Henan Province [grant numbers SB 201903018, LHGJ 20190611, and LHGJ 20200016] to YY and BW. Less than 2% of the population have B negative blood. Discussion: Two doses of the Chinese inactivated vaccine induced robust and rapid antibody expression and cellular immune responses. navigator.sendBeacon('https://www.google-analytics.com/collect', payload); COVID-19 vaccines can cause mild side effects after the first or second dose, including: Pain, redness or swelling where the shot was given Fever Fatigue Headache Muscle pain Chills Joint pain Nausea and vomiting Swollen lymph nodes Feeling unwell Most side effects go away in a few days. She is a 2020 J2 Achievement Award winner for her COVID-19 coverage. The mixed model distribution curves of log2-transformed neutralizing antibodies and log10-transformed cellular response with duration adjusted by age, sex, BMI, occupation, vaccination mode, duration since the second dose, interval between doses of vaccination, and ABO blood type were plotted using Prism 8.0 (GraphPad Software Inc., USA). Figure2 Quantitation of antibodies on days 1240 following administration of the Chinese inactivated vaccine. But recently, the genetics company 23andMe revealed preliminary data from their own study showing that a person's blood type, which is determined by the ABO gene, appears to affect susceptibility to coronavirus. This study was a multicenter, longitudinal, prospective, observational study conducted in two hospitals (Henan Provincial Peoples Hospital and Zhengzhou Municipal Chinese Medicine Hospital) and one institution (Henan Electric Power Survey and Design Institute) in central China. "Rh blood type was protective against SARS-CoV-2 infection, especially for those who were O-negative," they wrote. by Antibody responses to BNT162b2 vaccination in Japan: Monitoring vaccine efficacy by measuring IgG antibodies against the receptor-binding domain of SARS-CoV-2. Just because youre Type O doesnt mean youre in the clear. Results: Most participants [582/595; 146 male participants, 449 female participants; mean age 35 (2650 years)] rapidly developed neutralizing antibodies after two doses of the vaccine administered 3-weeks apart. People may start . We may earn commission from links on this page, but we only recommend products we back. Front Public Health. We are committed to bringing you researched, expert-driven content to help you make more informed decisions There were no changes in IFN- levels and CD4 T+ lymphocyte count on days 1 to 240 (B = 0.2, 95% CI 0.03 to 0.4, p = 0.09 and B = 0.004, 95% CI 0.005 to 0.003, p = 0.105; Tables3, 4) in participants stimulated with the SARS-CoV-2 S antigen. Fatigue, headaches, muscle and joint aches and fever are all potential side effects as well. Latest research and advice on side effects and allergic reactions related to COVID-19 vaccines. mesurer votre utilisation de nos sites et applications. Parameters of cell immune responses were evaluated by quantifying the levels of interferon (IFN)-, interleukin (IL)-6, and CD4, and counts of B-lymphocyte subsets in the plasma after overnight stimulation of whole blood with 2 g/mL SARS-CoV-2 spike peptides (Wuhan Huamei Biotechnology Ltd., Co., Wuhan, China) or dimethyl sulfoxide in whole-blood culture as a control, requiring only 2 mL blood (14). Clipboard, Search History, and several other advanced features are temporarily unavailable. Experts say more . 2021;144(1):109110. Additional . Opens in a new tab or window, Share on LinkedIn. Diarrhea. Although not all of these side effects may occur, if they do occur they may need . Follow-up visits were scheduled on days 130 to measure vital signs, review any solicited and unsolicited adverse events, and update medical and medication records. Clinics (Sao Paulo). Dynamic IgG seropositivity after rollout of CoronaVac and BNT162b2 COVID-19 vaccines in Chile: A sentinel surveillance study. We excluded 14 (2.4%) participants from the regression analysis and mixed model analysis due to missing data: 8 who withdrew their consent, 2 who did not answer age-related questions, 2 who missed a follow-up visit, and 2 who did not provide blood samples (Figure1). In contrast, we observed a decrease in the B-lymphocyte count and IL-6 level on days 1 to 240 in participants stimulated with the SARS-CoV-2 S antigen (B = 0.004, 95% CI 0.005 to 0.003; p = 0.008 and B = 0.004, 95% CI 0.006 to 0.002, p = 0.001, respectively; Tables5, 6; Figures3A, G). xhr.setRequestHeader('Content-Type', 'text/plain;charset=UTF-8'); The positive rate of neutralizing antibodies peaked at 97.7% at 6090 days, decreased, and stabilized at 82.9% at 181240 days post-vaccination. A higher IL-6 level was associated with older age, mixed-manufacturer vaccinations, intervals of less than 40 days between two doses of vaccination, and medical staff. Along with its needed effects, sars-cov-2 (covid-19) mrna-1273 vaccine (the active ingredient contained in Moderna COVID-19 Vaccine) may cause some unwanted effects. Progress and challenge of COVID-19 vaccine development. The early response observed 30 days after the second dose showed a boost effect linked to the same manufacturers scheme. doi:10.1002/jmv.27825, 10. -, Finsterer J, Scorza FA, Scorca CA. xhr.open('POST', 'https://www.google-analytics.com/collect', true); All Rights Reserved. ABO blood typing was performed using a test-tube method according to the manufacturers protocol (Chengdu Xiehe Ltd., Co., Chengdu, China). "Blood group O is significantly associated with reduced susceptibility to SARS-CoV-2. The participants in the study (mixed-manufacturer vaccination for the two doses) and control (same-manufacturer vaccination for both doses) groups remained in local community health centers for at least 30min after vaccination to monitor safety, and the occurrence of any adverse event during this observation period was recorded. Researchers think the clotting may be triggered by the high . According to Public Health England, most side-effects from two Covid vaccines - Pfizer/BioNTech and Oxford/AstraZeneca - are mild and short-lived. Comment on "SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fiber neuropathy by J. Finsterer. Yet these risks are relative, meaning people with type O blood are not immune to COVID-19. At 240 days after vaccination, the GMC of neutralizing antibodies in the mixed-manufacturer vaccination group decreased to 8.5 IU/mL, which was less than the decrease detected in the same-manufacturer vaccination group (20.5 IU/mL) (p < 0.001). All analyses, including linear regression, linear mixed models, and adverse effect analysis, were conducted using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) and plotted using Prism 8.0. Anderson's group examined data from Intermountain Healthcare, an integrated system of 24 hospitals and 215 clinics in Utah, Idaho, and Nevada. This finding suggests that cellular immune responses lasted longer than humoral responses in the vaccinated population. Treatment of these side effects is not at variance from similar conditions due to other causes. Desmecht S, Tashkeev A, El MM, Marechal N, Pere H, Tokunaga Y, et al. Domingo JL. By February 21, 2021, more than 46 million persons received at least 1 dose of an mRNA-based COVID-19 vaccine. If youre type O, you naturally make antibodies against Type A and Type B, Dr. Udden says. In both intervention and control groups, the positive rate of neutralizing IgG antibodies specific to the SARS-CoV-2 RBD slowly increased to 84.1% from 1 to 14 days, peaked at 97.7% from 60 to 90 days, and then slowly decreased and remained at 82.9% from 180 to 240 days after the second vaccination. Some women who received a Covid-19 vaccines have reported irregularities in their period following the shot, including heavier bleeding. Wang L, Fan JP, Xu Y, Wang JL, Wang MZ. BMI, body mass index; LSMD, least-square mean difference. Read on to find out if you're safe, and for more risky behavior to be aware of, know that It Only Takes This Long to Get COVID in a Room With Someone Who Has It. Of the 107,796 individuals tested for COVID-19, 11,468 patients tested positive. Typical side effects include pain at the injection site, fever, fatigue, headache, muscle pain, chills and diarrhoea. Nat Commun (2021) 12:1162. doi:10.1038/s41467-021-21444-5, 22. Feelings of having a fast-beating, fluttering or pounding heartbeat COVID can cause heart problems, too Having COVID-19 can also cause heart problems. *Correspondence: Yi Li, [email protected], These authors have contributed equally to this work, Advancing the Understanding of Emergence of SARS-CoV-2 Genetic Variants and COVID-19 Vaccine Efficacy: Essential Clinical and Molecular Insights and Breakthroughs, View all Lancet (2022) 399:221225. Based on our research, we rate FALSE the claim that 1 million "COVID-vaccine injuries" are reported in a CDC database. 2022 Dec 22;78:100157. doi: 10.1016/j.clinsp.2022.100157. Unauthorized use of these marks is strictly prohibited. This may explain why individuals with blood type A were more susceptible to SARS-CoV-2 infection than those with other blood types. Bookshelf YY and JX designed the study, analyzed the data, and wrote the manuscript. 2021;76:e3286. Blood type, the researchers found, stood out as a potential key difference between the two groups. 2021 John Wiley & Sons A/S. Our findings could provide evidence for an appropriate vaccination strategy against COVID-19. Hermel DJ, Spierling Bagsic SR, Costantini CL, Mason JR, Gahvari ZJ, Saven A. ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients. Wang Z, Liu H, Li Y, Luo X, Yang N, Lv M, et al. Epub 2023 Jan 9. A new large-scale study published in the journal Annals of Internal Medicinefound that your risk of catching COVID-19 is slashed if you have a particular blood type. The full coverage rate of the COVID-19 vaccination program has reached approximately 90% of the population required to be vaccinated in 2022 (10). Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19. Epub 2021 May 25. Either way, that would color how likely you are to not only get the virus but also how strong your symptoms are, he explains. Wong LP, Alias H, Siaw YL, Muslimin M, Lai LL, Lin Y, et al. Participants with an interval of <40 days between the doses of vaccination had lower levels of neutralizing antibodies than those with an interval of >40 days between the doses (B = 0.015 (0.010.021), 95% CI 0.010.021; p < 0.001) (Figure2E; Table2, and Table S3). eCollection 2021. The new study's co-author, Joel Ray, MD, of St. Michael's Hospital, suggested that people with these more resistant blood types may have already developed antibodies that can recognize certain aspects of the novel coronavirus and are therefore better prepared to fight it off. Most side effects are mild and normally last only a day or two. Except for blood type, all demographic and baseline characteristics were balanced between the intervention and control groups (Table1). Safety and reactogenicity of a liquid formulation of human rotavirus vaccine (porcine circovirus-free): A phase III, observer-blind, randomized, multi-country study. You'll always want to stay at your vaccination site for at least 15 minutes after you get the shot (30 minutes if you've had a severe allergic reaction before). You experience shortness of breath or swelling of the lips or face. doi:10.1001/jama.2021.19499, 11. The discovery of Type Os protective effect is crucial to building an understanding of how the virus works. We thank all study participants, the Henan Provincial Peoples Hospital data safety monitoring board, and the study-steering committee. The question of a possible relationship between blood type and disease risk has been a topic of active research since early in the pandemic. Additional research and review papers have confirmed that we're in more or less the same place: It looks like there really is an association between Type A blood and susceptibility to Covid and Type O blood and less susceptibility. Side effects can be a powerful deterrent stopping people from getting vaccinated. Lancet Infect Dis (2022) 22:47382. Pour en savoir plus sur la faon dont nous utilisons vos donnes personnelles, veuillez consulter notre politique relative la vie prive et notre politique en matire de cookies. } ); To date, coronavirus disease 2019 (COVID-19), a newly emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 600 million people worldwide and killed over 6 million people (1, 2). A linear regression analysis using a mixed-effect model showed that age, vaccination mode, occupation, interval between doses of vaccination, and vaccination duration were factors significantly associated with the levels of neutralizing antibodies (Tables13; Tables S1S7).

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